Welcome to the Chahine Lab!
We are interested in developing new therapies for cartilaginous tissues in the musculoskeletal system. Our focus is on spinal intervertebral discs, where we apply tools of bioengineering and biomechanics to understand degeneration and to develop regenerative strategies. We are also developing diagnostics biomarkers for back pain, the leading cause of disability worldwide.
Marshall SL, Jacobsen TD, Emsbo E, Murali A, Anton K, Liu JZ, Lu HH, Chahine NO. Three-Dimensional-Printed Flexible Scaffolds Have Tunable Biomimetic Mechanical Properties for Intervertebral Disc Tissue Engineering. ACS Biomaterials Science & Engineering 2021 7 (12), 5836-5849. doi: 10.1021/acsbiomaterials.1c01326
Forrester LA, Fang F, Jacobsen T, Hu Y, Kurtaliaj I, Roye BD, Guo XE, Chahine NO, Thomopoulos S. Transient neonatal shoulder paralysis causes early osteoarthritis in a mouse model. J Orthop Res. 2021 Nov 23. doi: 10.1002/jor.25225.
Ast MP, Gitlin A, Chahine NO, Grande D; Lementowski P. Motion and its Effects on the Cement Mantle – A Biomechanical Analysis of Femoral Stem Displacement during Implant Cementation”. American Journal of Orthopedic Research and Reviews, 4(1), p. 23. 2021 Jun 18 doi: 10.28933/ajorr-2021-06-1805.
Jacobsen TD, Hernandez PA, Chahine NO. Inhibition of toll-like receptor 4 protects against inflammation-induced mechanobiological alterations to intervertebral disc cells. Eur Cell Mater. 2021;41:576-591. Published 2021 May 20. doi:10.22203/eCM.v041a37
Coury JR, Nixon R, Collins M, Schwartz J, Chahine NO, Grande DA. Oral Administration of a Chemically Modified Curcumin, TRB-N0224, Reduced Inflammatory Cytokines and Cartilage Erosion in a Rabbit ACL Transection Injury Model. Cartilage. 2021 Apr;12(2):251-262. doi: 10.1177/1947603518815263.
Poon SC, Nellans K, Gorroochurn P, Chahine NO. Race, But Not Gender, Is Associated with Admissions into Orthopaedic Residency Programs. Clinical Orthopaedics and Related Research. 2020 Dec 3. doi: 10.1097/CORR.0000000000001553.
Hernandez PA, Jacobsen TD, Chahine NO. Actomyosin contractility confers mechanoprotection against TNFα-induced disruption of the intervertebral disc. 2020, Science Advances; 6(34):eaba2368. doi: 10.1126/sciadv.aba2368.
Wagner EK, Vedadghavami A, Jacobsen TD, Goel SA, Chahine NO, Bajpayee AG. Avidin grafted dextran nanostructure enables a month-long intra-discal retention. 2020, Scientific Reports;10(1):12017. doi: 10.1038/s41598-020-68351-1.
Jacobsen HE, Khan AN, Levine ME, Filippi CG, Chahine NO. Severity of intervertebral disc herniation regulates cytokine and chemokine levels in patients with chronic radicular back pain. Osteoarthritis and Cartilage. 2020, 28(10):1341-1350. doi: 10.1016/j.joca.2020.06.009.
Hernandez PA, Jacobsen TD, Barati Z, Chahine NO. Confocal scanning of intervertebral disc cells in 3D: Inside alginate beads and in native microenvironment. JOR Spine. 2020 Jul 15;3(4):e1106. doi: 10.1002/jsp2.1106.
Poon S, Nellans K, Crabb R, Rothman A, Wendolowski SF, Kiridly D, Gecelter R, Akerman M, Chahine NO. Academic Metrics Do Not Explain the Underrepresentation of Women in Orthopaedic Training Programs. 2019, Journal of Bone and Joint Surgery. 2019;101:e32(1-8).
Poon S, Nellans K, Rothman A, Crabb R, Wendolowski SF, Kiridly D, Gecelter R, Gorroochurn P, Chahine NO. Underrepresented Minority Applicants Are Competitive for Orthopaedic Surgery Residency Programs, but Enter Residency at Lower Rates. 2019, The Journal of the American Academy of Orthopaedic Surgeons. 27(21):e957-e968. doi: 10.5435/JAAOS-D-17-00811.
Fearing BV, Hernandez PA, Setton LA, Chahine NO. Mechanotransduction and cell biomechanics of the intervertebral disc. 2018, JOR Spine. e1026. doi: 10.1002/jsp2.1026.
Clyne AM, Marcolongo M, Darling EM, Chahine NO. Translating Mechanobiology to the Clinic: A Panel Discussion from the 2018 CMBE Conference. 2018, Cell and Molecular Bioengineering, Vol 11: 531.
Coury JR, Nixon R, Collins M, Schwartz J, Chahine NO, Grande DA. Oral Administration of a Chemically Modified Curcumin, TRB-N0224, Reduced Inflammatory Cytokines and Cartilage Erosion in a Rabbit ACL Transection Injury Model. 2018, Cartilage.
Shah BS, Burt KG, Jacobsen T, Fernandes TD, Alipui DO, Weber KT, Levine M, Chavan SS, Yang H, Tracey KJ, Chahine NO. High mobility group box-1 induces pro-inflammatory signaling in human nucleus pulposus cells via toll-like receptor 4-dependent pathway. 2018, Journal of Orthopedic Research.
Stefani RM, Halder SS, Estell EG, Lee AJ, Silverstein AM, Sobczak E, Chahine NO, Ateshian GA, Shah RP, Hung CT. A Functional Tissue-Engineered Synovium Model to Study Osteoarthritis Progression and Treatment. 2018, Tissue Engineering Part A.
Shah BS, Chahine NO. Dynamic Hydrostatic Pressure Regulates Nucleus Pulposus Phenotypic Expression and Metabolism in a Cell Density-Dependent Manner. J Biomech Eng. 2018 Feb 1;140(2).
Khan AN, Jacobsen HE, Khan J, Filippi CG, Levine M, Lehman RA Jr, Riew KD, Lenke LG, Chahine NO. Inflammatory biomarkers of low back pain and disc degeneration: a review. Ann N Y Acad Sci. 2017 Dec;1410(1):68-84
Clyne AM, Darling EM, Chahine NO, Discovering the Keys: Transformative and Translational Mechanobiology. 2017, Cellular and Molecular Bioengineering, Volume 10, Issue 4, pp 273–274.
Nguyen Q, Jacobsen TJ, Chahine NO, Effects of Inflammation on Multi-Scale Biomechanical Properties of Cartilaginous Cells and Tissues. ACS Biomaterials Science and Engineering. In Press. DOI: 10.1021/acsbiomaterials.6b00671
Drakos M, Murphy C, DeSandis B, Gott M, Chinitz N, Grande D, Chahine NO., 2017, Biomechanical analysis of suture anchor vs tenodesis screw for FHL transfer. Foot and Ankle International. 38(7):797-801
Nguyen QT, Norelli J, Graver A, Eckstein C, Schwartz J, Chowdhury F, Drakos MC, Grande DA*, Chahine N.O.*. Therapeutic Effects of Doxycycline on the Quality of Spontaneous and Surgical Repair of Lacerated Achilles Tendon. American Journal of Sports Medicine, In Press, Epub 2017 Jul 1 (* co-corresponding authors).
Maidhof R; Rafiuddin A, Chowdhury F, Jacobson, T, Chahine, N.O.; 2017, Timing of Mesenchymal Stem Cell Delivery Impacts the Fate and Therapeutic Potential in Intervertebral Disc Repair. Journal of Orthopedic Research. 35(1):32-40. doi: 10.1002/jor.23350
Weber KT, Quraishi SA, Alipui DO, Overby C, Levine M, Bloom O, Chahine N.O., 2016, Serum levels of the Pro-Inflammatory Cytokines IL-6 and TNF-alpha vary based on Diagnoses in subjects with low back pain. Arthritis Research and Therapy, 18(1):3.
Weber KT, Satoh S, Alipui DO, Vironjapa J, Levine M, Sison C, Quraishi SA, Bloom O, Chahine N.O., 2015, Exploratory study for identifying systemic biomarkers that correlate with pain response in patients with intervertebral disc disorders. Immnunologic Research. 63(1) 170-180.
Weber KT, Jacobsen TJ, Maidhof R, Virojanapa J, Overby C, Bloom O, Quraishi S, Levine M, Chahine NO, 2015, Developments in Intervertebral Disc Disease Research: Pathophysiology, Mechanobiology and Therapeutics. Current Reviews in Musculoskeletal Medicine. 8(1)18-31
Maidhof, R; Jacobsen, T; Papatheodorou, A; Chahine N.O., 2014. Effect of Inflammation on the Osmotic Properties of Nucleus Pulposus Cells. PLOS One, 9(6):e99621.